A Bodipy-Based Water-Soluble Fluorescent Probe For Mitochondria Targeting

Keywords

Cytotoxicity; Fluorescent probes; Imaging agents; Mitochondria targeting; Photophysics

Abstract

A water-soluble fluorescent mitochondrial targeting probe is reported. The probe bears a BODIPY-based fluorophore, two triphenylphosphonium (TPP) groups as mitochondrial targeting moieties, and two PEG groups to increase water solubility and enhance biocompatibility. As a mitochondria-selective fluorescent probe, the new BODIPY derivative exhibited many desirable properties, such as water solubility, high fluorescence quantum yield, solvent independent photophysical properties, pH insensitivity, good photostability, low cytotoxicity, and excellent mitochondrial targeting ability. Fluorescence microscopy colocalization experiments demonstrated the ability of this new probe to target mitochondria within living cells for bioimaging.

Publication Date

6-1-2016

Publication Title

European Journal of Organic Chemistry

Volume

2016

Issue

16

Number of Pages

2851-2857

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/ejoc.201600238

Socpus ID

84971261006 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84971261006

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