Micrornas And The Metabolic Hallmarks Of Aging

Keywords

Aging; Inflammation; Metabolism; Microbiome; miRNA; Mitochondria

Abstract

Aging, the natural process of growing older, is characterized by a progressive deterioration of physiological homeostasis at the cellular, tissue, and organismal level. Metabolically, the aging process is characterized by extensive changes in body composition, multi-tissue/multi-organ insulin resistance, and physiological declines in multiple signaling pathways including growth hormone, insulin/insulin-like growth factor 1, and sex steroids regulation. With this review, we intend to consolidate published information about microRNAs that regulate critical metabolic processes relevant to aging. In certain occasions we uncover relationships likely relevant to aging, which has not been directly described before, such as the miR-451/AMPK axis. We have also included a provocative section highlighting the potential role in aging of a new designation of miRNAs, namely fecal miRNAs, recently discovered to regulate intestinal microbiota in mammals.

Publication Date

11-5-2017

Publication Title

Molecular and Cellular Endocrinology

Volume

455

Number of Pages

131-147

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.mce.2016.12.021

Socpus ID

85009212513 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85009212513

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