Efficacy Of Different Compositions Of Cerium Oxide Nanoparticles In Tumor-Stroma Interaction

Keywords

Cancer; Cancer Therapy; Cerium Oxide Nanoparticles; Melanoma; Nanomedicine; Tumor-Stroma-Interaction

Abstract

The biomedical application of cerium oxide nanoparticles (nanoceria) is a focal point of research for a few years. The biochemical effects of nanoceria depend on various factors including particle size, oxidation state of cerium, oxygen vacancies on the surface, use of dispersants or coatings, pH and cell type. Due to their autocatalytic redox-activity, these particles are considered to act as a specific anti-cancer tool with less side effects on healthy cells and tissues, as the particles kill tumor cells, while protecting healthy cells from oxidative damage. In the present study, four different types of nanoceria were investigated with regard to their impact on biochemical parameters in vitro, which play a pivotal role in tumor-stroma interaction. The obtained data and presented in vitro test parameters will be helpful in designing nanoceria compositions, which are ideally suited for anticancer therapy, either as a 'stand alone drug' or in combination with other chemotherapeutics.

Publication Date

12-1-2017

Publication Title

Journal of Biomedical Nanotechnology

Volume

13

Issue

12

Number of Pages

1735-1746

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1166/jbn.2017.2452

Socpus ID

85047603338 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85047603338

This document is currently not available here.

Share

COinS