Htert C250T Promoter Mutation And Telomere Length As A Molecular Markers Of Cancer Progression In Patients With Head And Neck Cancer
Keywords
Head and neck cancer; Molecular markers; Telomerase reverse transcriptase promoter mutation; Telomere length
Abstract
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth leading cause of cancer worldwide, representing over half a million incidents every year. Cancer cells, including HNSCC, are characterized by increased telomerase activity. This enzymatic complex is active in ∼90% of all cancer types and is responsible for the lengthening of telomeres. Highly recurrent point mutations in the human telomerase reverse transcriptase (hTERT) promoter have recently been reported in a number of human neoplasms. The aim of the present study was to analyze the prevalence of the hTERT promoter C250T mutation and telomere length in the blood leukocytes of 61 patients with HNSCC and 49 healthy individuals. Quantitative polymerase chain reaction identified the hTERT promoter mutation in 36% of patients with HNSCC. To the best of our knowledge this is first report indicating the presence of shorter telomeres in early stage tumors. In addition, the results suggest that the C250T hTERT promoter mutation and telomere length assessment may serve as important molecular markers of HNSCC progression.
Publication Date
7-1-2017
Publication Title
Molecular Medicine Reports
Volume
16
Issue
1
Number of Pages
441-446
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.3892/mmr.2017.6590
Copyright Status
Unknown
Socpus ID
85020746075 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/85020746075
STARS Citation
Barczak, Wojciech; Suchorska, Wiktoria M.; Sobecka, Agnieszka; Bednarowicz, Karolina; and Machczynski, Piotr, "Htert C250T Promoter Mutation And Telomere Length As A Molecular Markers Of Cancer Progression In Patients With Head And Neck Cancer" (2017). Scopus Export 2015-2019. 5872.
https://stars.library.ucf.edu/scopus2015/5872