Increased Detection Of Precancerous Cervical Lesions With Adjunctive Dynamic Spectral Imaging

Keywords

Biopsy; Cervix uteri; CIN2+; Colposcopy; Dynamic spectral imaging

Abstract

Objective: To validate, in US community-based colposcopy clinics, previous reports of increased detection of high-grade cervical intraepithelial neoplasia (CIN2+) with biopsies selected using dynamic spectral imaging (DSI) mapping after standard colposcopy. Study design: Cross-sectional observational study of 26 colposcopists across nine clinics recruiting consecutive colposcopy patients. Standard assessment with biopsy selections was completed before seeing the DSI map which was subsequently interpreted and used for additional biopsies per clinical judgment. Primary measure was the number of women with CIN2+ detected by DSI-assisted biopsies, over those detected by standard colposcopy biopsies. Results: A total of 887 women were recruited. After exclusions, 881 women and 1,189 biopsies were analyzed. Standard biopsy detected 78 women with CIN2+ and DSI-assisted biopsies another 34, increasing the detection rate from 8.85% to 12.71% (p=0.00016). This was achieved with 16.16% of DSI-assisted biopsies finding CIN2+ compared to 13.24% for the preceding standard biopsies. For secondary specificity analysis, 431 women had only

Publication Date

9-28-2017

Publication Title

International Journal of Women's Health

Volume

9

Number of Pages

717-725

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.2147/IJWH.S144577

Socpus ID

85034982694 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85034982694

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