Keywords
Cerium oxide nanoparticles, soft particle electrokinetics, catalase activity, polyacrylic acid, molecular weight
Abstract
The application of Cerium oxide nanoparticles (CNPs) for therapeutic purposes requires a stable dispersion of nanoparticles in biological environment. The objective of this study is to tailor the properties of polyelectrolyte coated CNPs as a function of molecular weight to achieve a stable and catalytic active dispersion. This was achieved by coating CNPs with polyacrylic acid (PAA) which increased the dispersion stability of CNPs and enhanced the catalytic ability. The stability of PAA coating was analysed using the change in the Gibbs free energy computed by Langmuir adsorption model. The adsorption isotherms were determined using soft particle electrokinetics which overcomes the challenges presented by other techniques. The Gibbs free energy was highest for PAA coated CNPs by 250 kg/mole indicating the most stable coating. The free energy for PAA 100 kg/mole coated CNPs is 85% lower than the PAA250 coated CNPs. This significant difference is caused by the strong adsorption of PAA100 on CNPs. Catalytic activity of PAA-CNPs is accessed by the catalase enzymatic activity of nanoparticles. The catalase activity was higher for PAA coated CNPs as compared to bare CNPs which indicated preferential adsorption of hydrogen peroxide induced by coating. Apart from PAA coating the catalase activity is also affected by the structure of the coating layer.
Notes
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Graduation Date
2013
Semester
Fall
Advisor
Seal, Sudipta
Degree
Master of Science in Materials Science and Engineering (M.S.M.S.E.)
College
College of Engineering and Computer Science
Department
Materials Science Engineering
Degree Program
Materials Science and Engineering
Format
application/pdf
Identifier
CFE0005410
URL
http://purl.fcla.edu/fcla/etd/CFE0005410
Language
English
Release Date
June 2015
Length of Campus-only Access
1 year
Access Status
Masters Thesis (Open Access)
Subjects
Dissertations, Academic -- Engineering and Computer Science, Engineering and Computer Science -- Dissertations, Academic
STARS Citation
Saraf, Shashank, "Tailoring The Properties Of Polyelectrolyte Coated Cerium Oxide Nanoparticles As A Function Of Molecular Weight" (2013). Electronic Theses and Dissertations. 2894.
https://stars.library.ucf.edu/etd/2894