Keywords
Doyle s catalyst, Podocarpic acid, cancer, tubercolosis, dirhodium;
Abstract
Podocarpic acid (a diterpenoid resin acid extracted from the Podocarpacea specie of plants) has shown cytotoxicity against carcinoma of the nasopharynx. Since this discovery has been made, research has been performed in order to alter the structure of the resin acid so as to increase the anticancer activity. The carboxylic acid and phenol functional groups, which are present in podocarpic acid, make it possible to synthesize new derivatives selectively at the C-15, C-13, and C-7 positions as well as by substitution of the phenol hydroxyl group. Thus numerous derivatives can be prepared, in high yield, for the purpose of investigating their potential, as new drug leads for the treatment of cancer. In this study, Doyle's catalyst (Dirhodium tetrakis caprolactamate) was used to form a novel derivative in high yield (85%) which contained a 3-membered aziridine ring at the C-6 and C-7 position. The main thrust of this research involved the formation a series of novel derivatives of the aziridine compound by utilizing phenol and m-chlorophenol as nucleophiles to open the aziridine ring. These novel compounds will now be sent to the National Institute of Health (NIH) for bioassay against 60 human cancer cell lines.
Notes
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Graduation Date
2007
Semester
Summer
Advisor
Miles, Howard
Degree
Master of Science (M.S.)
College
College of Sciences
Department
Chemistry
Degree Program
Industrial Chemistry
Format
application/pdf
Identifier
CFE0001759
URL
http://purl.fcla.edu/fcla/etd/CFE0001759
Language
English
Release Date
July 2008
Length of Campus-only Access
None
Access Status
Masters Thesis (Open Access)
STARS Citation
Rhoden, Stephen, "Synthesis Of Novel Aziridine Derivatives Of Podocarpic Acid" (2007). Electronic Theses and Dissertations. 3316.
https://stars.library.ucf.edu/etd/3316