HIV, T cell, Modeling, Equilibrium Points
We examine an early model for the interaction of HIV with CD4+ T cells in vivo and define possible parameters and effects of said parameters on the model. We then examine a newer, more simplified model for the interaction of HIV with CD4+ T cells that also considers four populations: uninfected T cells, latently infected T cells, actively infected T cells, and free virus. The stability of both the disease free steady state and the endemically infected steady state are examined utilizing standard methods and the Routh-Hurwitz criteria. We show that if N, the number of infectious virions produced per actively infected T cell, is less than a critical value, , then the uninfected state is the only steady state in the non negative orthant, and this state is stable. We establish an expression for . If , then the uninfected steady state is unstable, and the endemically infected state can be stable or unstable, depending on the value of the parameters utilized.
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Mohapatra, Ram N.
Master of Science (M.S.)
College of Arts and Sciences
Length of Campus-only Access
Masters Thesis (Open Access)
Comerford, Amy, "On Modeling HIV Infection Of Cd4+ T Cells" (2006). Electronic Theses and Dissertations. 869.