Silica-based multimodal/multifunctional nanoparticles for bioimaging and biosensing applications

    Authors

    P. Tallury; K. Payton;S. Santra

    Comments

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    Abbreviated Journal Title

    Nanomedicine

    Keywords

    fluorescence imaging; MRI; multimodal/multifunctional nanoparticles; nanobioimaging; nanobiosensing; silica nanoparticles; COATED MAGNETIC NANOPARTICLES; APTAMER-CONJUGATED NANOPARTICLES; DYE-DOPED NANOPARTICLES; MN/ZNS QUANTUM DOTS; FLUORESCENT NANOPARTICLES; CANCER-CELLS; BIOCONJUGATED NANOPARTICLES; LUMINESCENT NANOPARTICLES; CARCINOEMBRYONIC ANTIGEN; BIOLOGICAL APPLICATIONS; Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology

    Abstract

    In the last decade, the field of nanoparticle (NP) technology has attracted immense interest in bioimaging and biosensing research. This technology has demonstrated its capability in obtaining sensitive data in a noninvasive manner, promising a breakthrough in early-stage cancer diagnosis, stem cell tracking, drug delivery, pathogen detection and gene delivery in the near future. However, successful and wide application of this technology relies greatly on robust NP engineering and synthesis methodologies. The NP development steps involve design, synthesis, surface modification and bioconjugation. Each of these steps is critical in determining the overall performance of NPs. It is desirable to obtain NPs that are highly sensitive, stable, imageable, biocompatible and targetable. It is also desirable to obtain multimodal/multifunctional NPs that will enable imaging/sensing of the target using multiple imaging/sensing modalities. In this review, we focus on silica NPs that have been developed for biosensing applications and silica-based multimodal/multifunctional NPs for bioimaging applications.

    Journal Title

    Nanomedicine

    Volume

    3

    Issue/Number

    4

    Publication Date

    1-1-2008

    Document Type

    Review

    Language

    English

    First Page

    579

    Last Page

    592

    WOS Identifier

    WOS:000258612700022

    ISSN

    1743-5889

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