Visible light mediated killing of multidrug-resistant bacteria using photoacids

    Authors

    Y. Luo; C. M. Wang; P. Peng; M. Hossain; T. L. Jiang; W. Fu; Y. Liao;M. Su

    Comments

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    Abbreviated Journal Title

    J. Mat. Chem. B

    Keywords

    PSEUDOMONAS-AERUGINOSA; INTRAVENOUS COLISTIN; COMBINATION THERAPY; INFECTIONS; TOXICITY; PH; NANOPARTICLES; MODEL; METHANESULFONATE; PHARMACOKINETICS; Materials Science, Biomaterials

    Abstract

    Increasing acidity is a promising method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. However, conventional ways of pH control are not reversible, which can cause continuous changes in cellular and biological behaviours and are harmful to the host. Utilizing a photoacid that can reversibly alter pH over two units, we demonstrated a strong bacterial inhibition assisted by visible light. The pH value of the solution reverts back to the original level immediately after the irradiation is stopped. If a photoacid is combined with colistin, the minimum inhibitory concentration (MIC) of colistin on multidrug-resistant (MDR) Pseudomonas aeruginosa can be improved similar to 32 times (from 8 to 0.25 mu g mL(-1)), which significantly decreases the toxicity of colistin in clinics. Evidenced by the extremely low toxicity of the photoacid, this strategy is promising in MDR bacteria killing.

    Journal Title

    Journal of Materials Chemistry B

    Volume

    1

    Issue/Number

    7

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    997

    Last Page

    1001

    WOS Identifier

    WOS:000314800500012

    ISSN

    2050-750X

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