Title

Visible light mediated killing of multidrug-resistant bacteria using photoacids

Authors

Authors

Y. Luo; C. M. Wang; P. Peng; M. Hossain; T. L. Jiang; W. Fu; Y. Liao;M. Su

Comments

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Abbreviated Journal Title

J. Mat. Chem. B

Keywords

PSEUDOMONAS-AERUGINOSA; INTRAVENOUS COLISTIN; COMBINATION THERAPY; INFECTIONS; TOXICITY; PH; NANOPARTICLES; MODEL; METHANESULFONATE; PHARMACOKINETICS; Materials Science, Biomaterials

Abstract

Increasing acidity is a promising method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. However, conventional ways of pH control are not reversible, which can cause continuous changes in cellular and biological behaviours and are harmful to the host. Utilizing a photoacid that can reversibly alter pH over two units, we demonstrated a strong bacterial inhibition assisted by visible light. The pH value of the solution reverts back to the original level immediately after the irradiation is stopped. If a photoacid is combined with colistin, the minimum inhibitory concentration (MIC) of colistin on multidrug-resistant (MDR) Pseudomonas aeruginosa can be improved similar to 32 times (from 8 to 0.25 mu g mL(-1)), which significantly decreases the toxicity of colistin in clinics. Evidenced by the extremely low toxicity of the photoacid, this strategy is promising in MDR bacteria killing.

Journal Title

Journal of Materials Chemistry B

Volume

1

Issue/Number

7

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

997

Last Page

1001

WOS Identifier

WOS:000314800500012

ISSN

2050-750X

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