Abstract
Prostate cancer is one of the leading causes of death for men in America as approximately 1 in 41 men will have prostate cancer. In this research, we focus on enzalutamide-resistant prostate cancer cells as cell resistance to enzalutamide is a prevalent obstacle in treating prostate cancer. We tested a novel compound library at different doses and observed each compound's efficacy in inducing apoptosis in enzalutamide-resistant cells. Furthermore, we analyzed the mechanism by which apoptosis was induced in compounds that showed a high efficacy at lower doses. Overall, we found that Darapladib shows promising results in treating cells that have acquired enzalutamide resistance.
Thesis Completion
2022
Semester
Spring
Thesis Chair/Advisor
Borgon, Robert
Degree
Bachelor of Science (B.S.)
College
College of Medicine
Department
Burnett School of Biomedical Sciences
Degree Program
Biomedical Sciences
Language
English
Access Status
Open Access
Release Date
5-1-2022
Recommended Citation
Sanghvi, Parshva A., "A Novel Drug to Induce Apoptosis in Advanced Prostate Cancer Cells" (2022). Honors Undergraduate Theses. 1202.
https://stars.library.ucf.edu/honorstheses/1202