Abstract
Serotonin has been widely explored in the brain. Recently, there have been new findings on how serotonin works in the periphery. Serotonin is introduced to the periphery by the enterochromaffin cells and metabolized by the liver and lung. Studies have shown that serotonin plays a role in controlling lung cancer. However, the mechanism by which it initiates tumor formation has not been fully explored. Cell viability was measured in several lung adenocarcinoma cell lines treated with serotonin to study this effect. In GFP-labelled cells, fluorescence intensity was measured for quantification of cell viability. Our data showed an overall increase in viability when serotonin concentration was increased, which is significant because it shows that serotonin affects lung cancer progression. We will look at how serotonin works on tumor cells compared to endothelial cells and its effect on immune system activation. This study hopes to inspire future anti-angiogenesis and immunotherapy studies of lung cancer by understanding this interaction.
Thesis Completion
2022
Semester
Fall
Thesis Chair/Advisor
Zhang, Wencai
Degree
Bachelor of Science (B.S.)
College
College of Medicine
Department
Burnett School of Biomedical Sciences
Degree Program
Biomedical Sciences
Language
English
Access Status
Open Access
Release Date
12-15-2022
Recommended Citation
Ntabo, Jessy K., "Serotonin's Proliferative Effects on Lung Cancer Cell Lines" (2022). Honors Undergraduate Theses. 1288.
https://stars.library.ucf.edu/honorstheses/1288