Abstract

Serotonin has been widely explored in the brain. Recently, there have been new findings on how serotonin works in the periphery. Serotonin is introduced to the periphery by the enterochromaffin cells and metabolized by the liver and lung. Studies have shown that serotonin plays a role in controlling lung cancer. However, the mechanism by which it initiates tumor formation has not been fully explored. Cell viability was measured in several lung adenocarcinoma cell lines treated with serotonin to study this effect. In GFP-labelled cells, fluorescence intensity was measured for quantification of cell viability. Our data showed an overall increase in viability when serotonin concentration was increased, which is significant because it shows that serotonin affects lung cancer progression. We will look at how serotonin works on tumor cells compared to endothelial cells and its effect on immune system activation. This study hopes to inspire future anti-angiogenesis and immunotherapy studies of lung cancer by understanding this interaction.

Thesis Completion

2022

Semester

Fall

Thesis Chair/Advisor

Zhang, Wencai

Degree

Bachelor of Science (B.S.)

College

College of Medicine

Department

Burnett School of Biomedical Sciences

Degree Program

Biomedical Sciences

Language

English

Access Status

Open Access

Release Date

12-15-2022

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