Abstract
This project introduces a novel ultrasonic shearing-based fabrication method for synthesizing nanobubbles, which can then be utilized as a platform for any theranostic applications in clinical medicine, such as drug/gene delivery systems. Our standard in situ sonochemical synthesis of nanobubbles incorporates a perfluorocarbon gas core (300 μl) and an albumin outer shell, which are then incorporated into phosphate-buffered saline (4 ml) and later sonicated with a US probe. The initial optimization phase consisted of experimenting with various amounts of human serum albumin (HSA), which stabilizes the nanobubble gas core. Of the parameters (20 mg, 40 mg, and 80 mg HSA), 40 mg HSA significantly outperformed (pin vivo imaging nanobubbles in the liver. A continuation of this project will continue to optimize and expand on the theranostic applications of the US sheared nanobubbles in vivo and ex vivo in osteoporosis and the bone.
Thesis Completion
2022
Semester
Fall
Thesis Chair/Advisor
Razavi, Mehdi
Degree
Bachelor of Science (B.S.)
College
College of Medicine
Department
Burnett School of Biomedical Sciences
Degree Program
Biomedical Sciences (Neuroscience Track), Biotechnology
Language
English
Access Status
Open Access
Release Date
12-15-2023
Recommended Citation
Pattilachan, Tara M., "Novel Ultrasound Shearing-based Fabrication Method for Nanobubble Synthesis in Gene and Drug Delivery Systems" (2022). Honors Undergraduate Theses. 1549.
https://stars.library.ucf.edu/honorstheses/1549