This collection contains Honors in the Major theses completed in Medicine.

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Theses from 2022

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A Reflection on Modern Western Adolescent Transitional Care of Patients with Chronic Conditions, Samuel Schepps

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PI3K and PAK Pathway Inhibition Decreases NF2-associated Tumor Size in Mouse Allograft Model, Andrew T. Tran

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The Role of the Prefrontal Cortex and Stress in Huntington Disease-Mediated Aggression, Kadambari Vyas

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The Relationship Between Sarcopenia and Diabetes Among Different Ethnic Groups, Rachel K. Williams

Theses from 2021

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The Development of Luciferase Reporters for the Optimization of CRISPR Interference Gene Silencing of Mycobacterial L,D-Transpeptidases, Isabella Castellano

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High Rates of Misdiagnosis of Pediatric Acute-Onset Neuropsychiatric Syndrome and How to Reduce Them, Aliya Centner

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Developing A Self-Sanitizing Mask to Combat the Spread of Infectious Disease, Matthew Crawford

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COVID-19 Infection in Hypertensive Patients in Correlation with Race, Elizabeth Durkin

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Targeting T Cell Glycolysis to Mitigate Graft-versus-Host Disease, Kevin Ezhakunnel

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Exploring Interleukin 21 and Its Role in Humoral Immunity in the Mouse Model of Influenza Infection, Samantha E. Gallahan

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Paternal Ages and Genetic Diseases and Congenital Anomalies, Neda Hamood

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Next-generation Protein Sequencing (NGPS) For Determining Complete Sequences for Unknown Proteins and Antibodies, Alexis S. Howard

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Awareness of Genetic Predispositions that Increase the Risk of Breast Cancer, Carly Huber

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Using a Lubricin Reporter Cell to Test Current vs. Optimized Media Compositions, Sean M. Kennedy

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The Role of Islam in Establishing Women's Rights in the Muslim World, Assad Khan

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Role of RelA in Dormancy and ToxR Proteolysis in Vibrio cholerae, Zachary J. Malaussena

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Epinephrine Synthesizing Enzyme Expression in the Developing Central Nervous System: Implications for the Impact of Stress on Formative Brain Maturation, Meeti Mehta

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Using Genetics in a Model Organism to Understand Polyamine Transport, Victoria A. Millington

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Split Aptamer Sensor For Single Nucleotide Selective Target Detection, Jack E. Mordeson

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Concomitant Guillain-Barre Syndrome with COVID-19, Skylar A. Morongell

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The Psychological Benefits of a Remote Physical Activity Intervention in Young Adults with Autism Spectrum Disorder, Madisyn T. Pelchat

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Acoustic Detection of Developmental Dysplasia of the Hip in Models Representing Neonates, Pinak Raodeo

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Neuroglobin and its Role in the Recovery of Neuronal Cells in Hypoxic Conditions Using Hypoxia Inducible Factor– 1, Riya Shah

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Developing a Targeted Ultrasound-responsive Nanobubble-based Gene Delivery System for Osteoporosis Treatment, Angela Shar

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Involvement of Receptor Interacting Protein 2 in the Activation of 5-Lipoxygenase, Marianne Sia

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Identifying Pathways Affected by the HrpA RNA Helicase, Brandon Simons

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The Role of MS-818 in Altering Age-related Characteristics of an In Vitro Model of Senescence in Neural Stem Cells, Sandeep Sreerama

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Multifactorial Media Analysis via Design of Experiment for Type II Collagen in Primary Rabbit Chondrocytes, Javier A. Velez Toro

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Targeting T Cell Metabolism to Ameliorate Graft-versus-Host Disease, Karin Zikra

Theses from 2020

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Identification of Druggable Targets in a Schwannomatosis Patient-Derived Tumor Cell Line, Abdulrahman Allaf

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Non-Alcoholic Fatty Liver Disease and the Gut Microbiome: The Effects of Gut Microbial Metabolites on NAFLD Progression in a 2-Organ Human-on-a-Chip Model, Rachel H. Boone

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The Effects of Vaping on Oral Streptococci and Oral Inflammation, Matthew Caldwell

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The Effect of Using CRISPR/Cas9 Treatment to Delete the Myostatin Protein In Vivo and In Vitro, Marco Cardone

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Cerium Oxide Nanoparticles and Beneficial Bacteria: Two Novel Treatments for Eradicating Bacteria Associated with Prosthetic Infection?, Etta Conteh

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Comparison of Low Carbohydrate Diets on Renal and Glucose Function in Subjects with Type 2 Diabetes: A Systematic Review and Meta-analysis, Garrett A. Couch

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Detection of Point Mutations Conferring Gentamicin Resistance in Escherichia coli using a Split-G4 Probe, Michael J. Greenberg

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The Effect of a Senolytic Drug on Messenger RNA and Micro RNA Expression in Perigonadal Adipose Tissue of Young and Old Mice, Catalina Hernandez

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Effects of Maternal Thyroid Hypofunction on Fetal Brain Development During Pregnancy: Possible Links to Autism Spectrum Disorder, Caroline R. Hobson

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Isoform-Specific Expression of Adenylate Cyclase in Cardiac Development, Lauren A. Houchin

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Understanding Medical Error in Surgical Stapler Use: A Philosophical and Scientific Analysis, Jacob E. Howard

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Determining the Advantageous Acute Migraine Treatment: Rimegepant and Lasmiditan Review of Literature, Tiffany A. Johnson

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Variations in Diet Quality Among Undergraduate Students, William Johnson

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Investigating Aggression in Huntington Disease, Chloe E. LaRochelle

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Investigating the Effect of Ethanol on Wnt7a and its Potential Implications in Fetal Alcohol Spectrum Disorder, Erika Lytle

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The Effects of Roundup on the Life History, Stress Response, and Immune Function of the Yellow Fever Mosquito, Aedes aegypti, Lindsay E. Martin

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Memory T Cell Regulation of Innate Lymphoid Cell Associated Repair Proteins Following Influenza A Virus Vaccination and Infection, Mate Z. Nagy

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Retrograde Labelling and Visualization of the Intrinsic Autonomic Ganglia of the Rat Liver, Kennan J. Negrete

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Left Ventricular Strains during Late Filling in a Preclinical Model, Saar Peles

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Understanding Reasons for Electing Gap Years Between Undergraduate Education and Medical School and the Impact of Gap Years on the Student Experience of Medical Education, Haroon Rashid

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Nanopore-Based Metagenomic Comparison of Airway Colonizers Between Cystic Fibrosis Patients and Healthy Individuals, Anita Samadabadi

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Identification and Validation of Novel Antimalarials Targeting Plasmodium Aurora Kinases, Justin T. Shaw

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Regulation of the EGFR Epigenetic Landscape in Glioblastoma Multiforme, Anishaa Sivakumar

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Evalutation of Human Platelet Lysate in NK Cell Culture, Elizabeth Williamson

Theses from 2019

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The Analysis of the Impact of Trisomy 21 on Brain Morphometry in Humans, Yaser Ahmad

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Discovery and Characterization of Antimalarials Targeting Plasmodium Falciparum Protein Kinases, Alya Barq

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The Effects of Matrix Metalloproteinase-9 on CX3CL1 Shedding and Axon Retraction, Lauren A. Dobrie

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Elucidating the Role of Oxygen and Biotype in the Environmental Persistence of Vibrio Cholerae, Amy M. Freiberg

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Isolation of Characterization of an Endemic Population of Vibrio Cholerae in the Florida Indian River Lagoon, Carolina Ganan

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An Exploration of Public Misconceptions of Municipal Water Fluoridation Relating to Oral and Public Health, Thomas A. Hawkins

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Studies on the Potential Regulation of USP30 by Omi/HtrA2 Protease, Sunmi Jin

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Exploring Galvanic Replacement as a Method to Engineer Peroxidase-mimics Nanoparticles, Kuryn T. MaGloire

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Evaluating Lactobacillus Acidophilus as a Model Organism for Co-Culture Cancer Studies, Samuel A. Mikhail

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Development of Luminescent Tools for Use in the Study of Mycobacterium tuberculosis, Krista A. Moore

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The Presence of Pain Related Cytokines and Chemokines in Schwannomas and Their Potential Association with Chronic Pain in Schwannomatosis, Jackson D. Nagamoto

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Lower Osteocalcin is Linked to Genetic Polymorphisms in TNFRSF1A/1B and Mycobacterium Paratuberculosis infection among Rheumatoid Arthritis patients, Ahmad K. Odeh

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Micromanipulation and Genetic Analysis of Individual Sperm Cells for Sexual Assault Investigations, Amanda Penn

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Proposed Biomedical Applications of Zirconium-Based Metal-Organic Frameworks as Drug Delivery Systems, Ariel Margaret Perry-Mills

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Overview of Direct Thrombin Inhibitors for use in Staphylococcus Aereus Infections, Joseph C. Risler

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The Role of Activin A Signaling in Gastric Reflux-Related Diseases and the Progression to Esophageal Adenocarcinoma, Cedric J. Roudebush

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Determining the Potential Cleavage of Human Amyloid Beta Fibril Aggregations by the Human Matriptase Serine Protease Domain, Jonathan D. Ruiz

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Investigation of the Cell-Cycle Dependent Activity of the BRCA1-Rbbp8 Complex for Homologous Recombination, Jil Shah

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The Envelope Stress Response in Sedimentation-Resistant Escherichia Coli, Neel K. Shah

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Role of T-Bet in Production of Immunoglobulin Isotypes in an Influenza Setting, David Sidhom

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Application and Comparison of Active Learning Implementation Methods in Biochemistry Education, Dylan Thibaut

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A Meta-Analysis of Neuromyelitis Optica Epidemiology in Latin American Nations, Brittany M. Zengotita

Theses from 2018

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Can NoX1 Activity Initiate Parkinson's-Like Pathology in an Enteroendocrine Cell Line?, Evan Adler

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Characterization of Novel Antimalarials From Compounds Inspired By Natural Products Using Principal Component Analysis (PCA), Zarina Marie G. Balde

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Investigation of the Effects of Cobimetinib on Neurofibromatosis Type 2 Model Schwannoma Cells, Konstantin Brnjos

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Systematic Review and Meta-Analysis: Tuberculosis, TNFα Inhibitors, and Crohn's Disease, Brent L. Cao

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A Case-Study of the African Leopard (Panthera Pardus Pardus) Population on the Nambiti Private Game Reserve, Erica Castaneda

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The Effect of Mismatch Primers on the Efficiency of Amplification in Quantitative Polymerase Chain Reactions, Molly C. Dawkins

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Studies of Norspermidine Uptake in Drosophila Suggest the Existence of Multiple Polyamine Transport Pathways, Michael Dieffenbach

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Studies on E2 Conjugation Enzyme Partners of Mulan E3 Ubiquitin Ligase, Rebekah J. Fitzpatrick

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Reducing the Rate of Misdiagnosis of Postural Orthostatic Tachycardia Syndrome, Isabelle C. Gill

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Investigating the Role of the Gut Microbiome in Huntington Disease, Casey G. Hart

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Targeted Delivery of a Therapeutic Protein for the Treatment of Alzheimer's Disease, Heather Holman

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Bacteria That Resist Centrifugal Force, Nickolas Kessler

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Investigation of Aminoglycoside Induced Nanoparticle Self-Assemblies, Michael Leong

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Effects of Dietary Factors on the Incidence and Progression of Non-Alcoholic Fatty Liver Disease, Spencer L. Lessans

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Anatomical and Functional Assessment of Pnmt+ Neurons in the Mouse Hypothalamus and Cerebellum: Potential Roles in Energy Metabolism and Motor Control, Lake A. Lindo

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Investigating the Role of the Caspase-6 Cleavage Fragment of Mutant Huntingtin in Huntington Disease Pathogenesis, Jourdan A. McKinnis

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An Exploration into the Psychotic Symptoms Associated with Schizophrenia and Major Depressive Disorder, Kyndester I. Michael-Samaroo

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The Effects of Site-Directed Mutagenesis on Hemerythrin-like Protein Rv2633c, Kelly M. Rosch

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Development of Methods to Modulate Natural Killer Cells, Kari A. Shaver

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Parasympathetic Nerve Derived Exosomes Inhibit Hyperglycemia Induced Apoptosis in Cardiomyoblast Cells, Reetish K. Singla

Theses from 2017

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The Use of Hands-on Educational Pedagogy in A Standardized Science Curriculum, Sarah Alam

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Analysis of the Prevention of Biocorrosion Caused by Desulfovibrio alaskensis G20, Michael Boring

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The Role of Frabin (FGD4) in Aggressive Prostate Cancer, Alexia M. Bossan

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The Role of Breastfeeding in Mother-to-Child Transmission of HIV/AIDS: A Comparative Case Study of Three Countries, Anjali Cherukuri

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Testing Mice at Risk of Pancreatic Cancer for Altered Protein Pathways Found in Diabetes, Henley Cheung